How long does a full retatrutide titration take?

Stepping 2 mg every four weeks from 2 mg to 12 mg is six stages, which is 24 weeks. Slower steps of six weeks make it 36 weeks.

How many vials do I need for a full titration?

At a 10 mg vial, stepping 2 mg every four weeks to 12 mg, the whole ladder uses about 16.8 vials. The early stages are cheap and the top of the ladder is where the cost sits.

Do I have to reach 12 mg?

No. The ladder is a ceiling, not a target. Many reported protocols hold at 4, 6 or 8 mg indefinitely.

Retatrutide titration schedule

Every stage of the 2 mg to 12 mg ladder, in units to draw. Use the calculator for your own vial and water.

Peptulator, peptulator.com. Research use only, not medical advice.

The Protocol Pack, free

25 printable pages: dosing cards for the twelve most-used compounds at three water volumes, titration planners, a vial log, and five pages on what to do when it has already gone wrong.

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The maths is openThe formula is on every page and in the methodology. The code is one file with an automated test suite, run before each deploy.

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ReviewedDose ranges and half-lives checked 3 September 2026.

The schedule

Stage	Weekly dose	Draw	U-100 units	Vials used by end
Weeks 1–4	2 mg	0.4 mL	40 units	0.8
Weeks 5–8	4 mg	0.8 mL	80 units	2.4
Weeks 9–12	6 mg	1.2 mL	120 units	4.8
Weeks 13–16	8 mg	1.6 mL	160 units	8.0
Weeks 17–20	10 mg	2 mL	200 units	12.0
Weeks 21–24	12 mg	2.4 mL	240 units	16.8

Based on a 10 mg vial with 2 mL of bacteriostatic water (5 mg/mL) on a U-100 syringe, stepping every 4 weeks. Change any of that and the units change, so run your own numbers in the calculator above.

How to read it

Retatrutide is investigational and has no licensed titration schedule, because it has never been approved. The ladder below is the pattern most commonly reported: start at 2 mg weekly and step up 2 mg every four weeks. Some people step every six or eight weeks instead, and plenty stop well before 12 mg.

The point of a slow ladder is tolerability. Stepping faster than your side effects allow is the single most common reason people abandon a GLP-1 entirely.

A titration ladder is a maximum pace, not a target. Holding at a lower dose for longer is a normal outcome, not a failure.

Common questions

How long does a full retatrutide titration take?: Stepping 2 mg every four weeks from 2 mg to 12 mg is six stages, which is 24 weeks. Slower steps of six weeks make it 36 weeks.
How many vials do I need for a full titration?: At a 10 mg vial, stepping 2 mg every four weeks to 12 mg, the whole ladder uses about 16.8 vials. The early stages are cheap and the top of the ladder is where the cost sits.
Do I have to reach 12 mg?: No. The ladder is a ceiling, not a target. Many reported protocols hold at 4, 6 or 8 mg indefinitely.

Where to buyWhat to check before you order Vendor scorecardRanked vendors, at Peptide Bureau Build a full protocolThe stack builder at Peptide Bureau, about two minutes

All calculators and charts

Weight management (GLP-1 family)

Retatrutide calculator Vial, water and weekly dose to syringe units
Tirzepatide calculator The 2.5 to 15 mg ladder, converted
Semaglutide calculator The 0.25 to 2.4 mg ladder, converted
Cagrilintide calculator Amylin analogue, 0.3 to 4.5 mg weekly

Growth hormone axis

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CJC-1295 (no DAC) calculator No-DAC and DAC, mcg to units
CJC-1295 / Ipamorelin blend calculator The 5 mg + 5 mg blend, per component
Sermorelin calculator Nightly mcg doses to units
Tesamorelin calculator 1 to 2 mg daily, in units
Hexarelin calculator mcg doses to units
IGF-1 LR3 calculator Tens of mcg from very small vials
AOD-9604 calculator 300 mcg daily, in units
MOTS-c calculator 5 to 10 mg, two or three times a week

Repair, skin and blends

BPC-157 calculator mcg doses from a 5 or 10 mg vial
TB-500 calculator Loading and maintenance, in units
BPC-157 / TB-500 blend calculator The Wolverine stack, per component
GHK-Cu calculator 50 to 200 mg vials, mg doses
GLOW blend calculator The 70 mg blend, split per component
KLOW blend calculator The 80 mg blend, split per component

Other compounds

PT-141 calculator 0.5 to 2 mg, as needed
Melanotan II calculator mcg loading doses to units
NAD+ calculator 100 to 1,000 mg vials, 25 to 200 mg doses
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Epitalon calculator Short courses of 5 to 10 mg
Kisspeptin-10 calculator mcg doses to units
Glutathione calculator Hundreds of mg, or a 200 mg/mL solution

Dosage charts and schedules

Peptide reconstitution chart Concentration for every vial and water combination
Peptide dosing chart Printable unit tables for every compound
Retatrutide titration schedule (this page)
Tirzepatide titration schedule 2.5 to 15 mg in units, stage by stage
Semaglutide titration schedule 0.25 to 2.4 mg in units, stage by stage
KLOW dosage and frequency chart The 80 mg blend at 2, 3 and 4 mL, both phases
GLOW dosage chart The 70 mg blend, units to each peptide
Wolverine stack dosing chart BPC-157 + TB-500, blend and separate vials
MOTS-c dosage chart 5 and 10 mg vials at three water volumes
Tirzepatide reconstitution chart Every vial size, every water volume, the whole ladder
Retatrutide dosing chart 1 to 12 mg across 10, 20 and 30 mg vials
Printable dosing charts Four one-page charts to save, pin or print

Tools

Peptide calculator The general tool, any compound
Reconstitution calculator How much water to add, and why it matters
mg to units calculator Both directions, any concentration
Bacteriostatic water calculator Pick a volume that lands where you can read it
How to read an insulin syringe U-100 vs U-40, and the 2.5x error
The Protocol Pack Free 25-page printable reference
Where to buy Vendor notes and what to check first
1 mg to units on an insulin syringe The conversion table for every common concentration

Before you use these numbers This is a unit-conversion tool. It turns a vial strength and a water volume into a concentration, a draw volume and a syringe mark. It does not tell you what to take, whether to take it, or whether a compound is safe for you. Most compounds listed are sold for laboratory research and are not approved for human use. Nothing here is medical advice. Dosing decisions belong with a licensed clinician who knows your history. Always check the strength printed on your own vial rather than trusting a preset.